It is an essential element of the animal and vegetable life. It appears in some enzymes and, probably, it conditionates the use of some vitamins (B1). For these reasons it is frequently added to fertilizers and to pharmaceutical preparations (glycerphosphate and manganese hypophosphide). Its deficiency causes the chlorophyll decrease in the plants (that acquire a yellowish aspect) and disturbances in the bone tissues of the animals. Generally, the manganese compounds are not toxicant. However, the oxidizer properties of some permanganate can cause skin irritation and the inhalation of its vapors can be quite harmful.