Liquid and gaseous bromine presents a serious health hazard. The liquid rapidly attacks the skin and other tissues to produce irritation and necrosis. Exposure to vapors can cause painful irritation to the eyes and inflammation of the respiratory tract. The maximum concentration which is considered safe for an eight-hour exposure is less than 1 PPM. Plants for the manufacture or use of bromine should be designed to provide maximum safety precautions and good ventilation. Many bromine compounds have important physiological applications and are therefore employed in Medicine as sedatives, anesthetics and antiseptics.