Berkelium has no technological uses at present and its limited availability has precluded an extensive investigation of its properties.

It has been shown in experiments with rats and mice that actinide elements taken into the body tend to accumulate in the skelet. The radiations associated with these isotopes damage the body red-cell forming mechanism.

The toxicity of the individual isotopes varies, depending on the type of radioactivity and half-life. The maximum permissible burden of Bk 249 in the human skeleton is about 0,0004 micrograms.